Angelo Titonel was born in Cornuda, Italy. At a young age he moved to Milan, where he graduated from the "Castello Sforzesco" School of Applied Arts. He began working as a graphic designer and art director in international advertising agencies but later abandoned this career to devote himself to painting.

His first exhibit came in 1964, in Velbert (Essen), Germany. He then moved to Rome where, during the 1970s, he was recognized as one of the leading figures of Italian magic realism.

Titonel's numerous exhibitions include shows at, among others, the Museo Civico of Bologna (Italy, 1973); the Museum of Contemporary Art of Skopije (Macedonia, 1974); the European Parliament in Strasbourg (France, 1994); the Complesso del Vittoriano in Rome (2001); the Lausanne Olympic Museum (Switzerland, 2005); and the Palazzo Pubblico Antichi Magazzini del Sale in Siena (Italy, 2010).

Many other solo exhibitions have taken place throughout Europe and the United States over the years. Titonel has also been invited to several international Biennial and Quadrennial events and has been awarded numerous prizes and rave reviews.

His many prestigious commissions include the Quirinal Palace, the residence of the Italian head of State, for which he has painted portraits of the presidents of the Italian Republic and key historical characters, including Giuseppe Garibaldi, Giuseppe Mazzini, Massimo D'Azeglio and the Count of Cavour. He was also commissioned by the Vatican to paint the official portrait of the current pope, Benedict XVI.

Upon request from the Uffizi Gallery in Florence, he created a self-portrait for the Gallery's collection entitled "Artist Self-Portraits".

Numerous Italian and foreign critics have written about Titonel's work.

Since 1992 he has been living and working in Imola (Italy).